活体荧光眼底造影对长期2型糖尿病

小鼠视网膜血管损害的观察

Observation of RetinalBlood Vessel Damage in Mice with Long-term type 2 diabetes Mellitus by FluorescenceFundus Angiography

马红婕^{1, 2, 3}  张欣³ 唐仕波^{1, 2※}  汪建新³  汪振芳⁴

（1. 深圳爱尔眼科医院，广东  深圳，518000；2.中南大学爱尔眼科学院，湖南  长沙，418003；

 3.美国纽约州立大学布法罗分校眼科，美国  纽约；999039；4.中山大学中山眼科中心国家重点眼科研究所，广东  广州，510060）

中图分类号：R7747.1    文献标识码：A    文章编号：1674-7860(2015)24-0024-03    证型：DBG

【摘  要】目的：活体观察长期2型糖尿病小鼠视网膜血管的损害。方法：应用荧光眼底血管造影（FFA）活体观察视网膜血管，对长期2型糖尿病小鼠视网膜血管数量及渗漏状态进行综合评价。结果：眼底照相显示长期2型糖尿病小鼠视网膜可见动脉反光增强，静脉迂曲扩张，未见明显荧光素渗漏，但可见毛细血管网密度降低。结论：2型糖尿病小鼠的视网膜血管损害主要表现为血管退行性变，而非血管的渗漏。

【摘  要】2型糖尿病；荧光眼底血管造影

【Abstract】Objective: To observe the damage of retinalblood vessels in mice with long-term type 2 diabetes. Methods: The retinalblood vessels were observed by fluorescence fundus angiography (FFA)  and the number and situation of the retinalblood vessels and leakage of type 2 diabetic mice were observed and evaluated.Results: The fundus photography showed that the visibility of type 2 diabeticmice retinal arteries was enhanced and vein dilated, but no obvious fluoresceinleakage. Conclusion: The main manifestation of type 2 diabetic mice is retinalvascular damage, not the blood vessels.

【Keywords】Type 2 diabetes; Fluorescence Fundus Angiography

doi:10.3969/j.issn.1674-7860.2015.24.011

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